We investigated the effects on the suppression of blood pressure elevation and anti-arteriosclerosis action by the administration of refined Rice Kefiran for 30 days in stroke-prone spontaneously hypertensive rats (six-week-old male SHRSP/Hos rats) feeding on high-fat diet. In blood pressure recordings on the baseline, 15th, and 30th days, the administered group showed significantly lower values than the control group. In the measurement of total lipids, total cholesterol, and triglyceride, the administered group also showed significantly lower values than the control group. In the histopathological examination of the brain, the large artery, and the coronary artery for the control group, lipid deposition was detected in the basilar artery and the endomembrane of the aortic arch, adhesion of the intramural thrombi was observed in the aortic arch, and fibrin thrombi were observed in the intracoronary artery. The refined Rice Kefiran group showed lower-grade lesions than the control group and the lipid deposition in the endomembrane of the aortic arch was also detected at the low-grade. Consequently, it was suggested that Rice Kefiran showed suppression of blood pressure elevation and anti-arteriosclerosis action.
■Effect of refined Rice Kefiran on blood pressure and serum ACE activity in
SHRSP/Hos rats
Control group Refined Rice Kefiran Refined Rice Kefiran
（n=10） 100mg/kggroup 300mg/kggroup
（n=10） （n=10）
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Systolic blood pressure (mmHg)
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Baseline 163.5± 3.4 169.8± 5.2 156.6± 2.4
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15th day 186.5± 6.4 179.7± 2.4 168.6± 4.5a,b
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30th day 192.1± 3.0 181.9± 4.6aa 173.1± 4.0aa,b
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Diastolic blood pressure (mmHg)
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Baseline 124.2± 4.2 122.1± 2.3 136.4± 6.8
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15th day 139.2± 5.5 139.8± 2.4 136.5± 2.3
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30th day 158.9± 4.0 147.8± 3.4a 135.2± 3.9aa,bb
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ACE activity (U/I) 21.73± 0.29 20.28± 0.43aa 19.80± 0.60a
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Mean ± standard deviation. A significant difference to the control group: a, p < 0.05; aa, p < 0.01;
a significant difference to the refined Rice Kefiran 100mg/kg group: b, p < 0.05; bb, p < 0.01.
■Effect of refined Rice Kefiran on serum lipid in SHRSP/Hos rats
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Control group
（n=10）
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Refined Rice Kefiran
100mg/kggroup
（n=10）
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Refined Rice Kefiran
300mg/kggroup
（n=10）
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Total lipids
(mg/dL)
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973.00±27.01
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964.20±30.49
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897.40±18.40a
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Total cholesterol (mg/dL)
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495.60±13.57
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475.80±16.77
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450.30±12.29aa
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VLDL-cholesterol (mg/dL)
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174.03± 5.61
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152.25± 5.37a
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150.52± 4.63aa
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LDL-cholesterol (mg/dL)
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310.79± 9.57
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294.99±10.40
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272.77± 8.79aa
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HDL-cholesterol (mg/dL)
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24.30± 0.75
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23.81± 0.84
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23.54± 0.76
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Triglyceride
(mg/dL)
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46.30± 2.67
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41.40± 4.17
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28.40± 2.98aa,b
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VLDL-triglyceride (mg/dL)
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43.38± 3.28
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34.38± 3.46
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18.36± 1.78aa,bb
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LDL-triglyceride (mg/dL)
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4.56± 0.46
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3.43± 0.24a
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2.70± 0.46aa
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HDL-triglyceride (mg/dL)
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2.38± 0.13
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2.31± 0.15
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2.30± 0.17
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Mean ± standard deviation. A significant difference to the control group: a, p < 0.05; aa, p < 0.01;
a significant difference to the refined Rice Kefiran 100mg/kg group: b, p < 0.05; bb, p < 0.01.
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