The histamine contents in the cecal content and faeces were increased in rats loaded with cholesterol. This result shows that the excretion amount of sterol and organic acid is increased by the intake of the high-cholesterol diet to cause impairment of the intestinal environment, such as the intestinal flora. In the Rice Kefiran-fed groups, the histamine contents in faeces were significantly decreased in both the 1.5% and 3.0% groups. This result suggests that Rice Kefiran has an improvement action on the intestinal environment.
■Inhibition of intestinal histamine production by the intake of Rice Kefiran
in rats loaded with cholesterol
|
|
Control group
|
1.5% Rice Kefiran
group
|
3.0% Rice Kefiran
group
|
Plasma histamine
(μg/L)
|
13.2 ±3.5
|
12.1 ±4.0
|
17.5 ±1.2
|
Faecal histamine
(g/g)
|
2.42±0.59a
|
0.62±0.22b
|
0.82±0.21b
|
Faecal excretion of histamine
(μg/rat/day)
|
6.36±1.72a
|
1.86±0.70b
|
2.01±0.55b
|
Cecal histamine
(μg/g)
|
2.34±0.27a
|
0.87±0.34b
|
0.74±0.17b
|
Mean ± standard error (n=6). a,bValues with different superscriptions are significantly different (p < 0.05).
|
